EasySep™小鼠TIL（CD45）正选试剂盒
用于乳腺细胞培养的MammoCult™培养基
成分明确、无血清的乳腺球和肿瘤球培养基
MammoCult™是乳腺球和肿瘤球培养领域发表文献最多的商用培养基。乳腺球培养源自原代乳腺组织或细胞系，而肿瘤球则培养自多种组织的原代肿瘤细胞和癌细胞系。该培养基已成功应用于多种乳腺癌细胞系的肿瘤球生成，包括MCF7、MCF10A、SKBR3、MDA-MB-231、AU565、SUM149和BT474等。除被乳腺癌研究学者使用外，这款成分明确的无血清培养基亦适用于卵巢、肺、结肠等多组织来源的细胞球培养实验。
培养乳腺球和肿瘤球
三维球体培养技术相较于传统单层培养具有更高的生理相关性。乳腺球培养体系通过将乳腺上皮细胞以低密度接种，防止细胞贴壁生长，使其以悬浮球状团簇形式扩增。该体系能够在体外扩增乳腺干细胞和祖细胞，并支持乳腺癌干细胞及细胞系的肿瘤球培养。观看视频，了解如何使用MammoCult™培养基轻松生成乳腺球和肿瘤球。
乳腺癌研究
乳腺癌研究人员选用MammoCult™培养基培养乳腺癌干细胞或细胞系来源的肿瘤球。除MammoCult™外，我们提供全套癌症研究工具，包括专用细胞培养基、细胞分选试剂及干细胞检测试剂盒，助力您的研究。观看视频，了解 和 如何推动乳腺癌研究进展。
为何要使用 MammoCult™ ？
- 无血清、化学成分确定的配方
- 可生成大量可传代的乳腺球与肿瘤球
- 支持乳腺癌细胞系的长期维持培养
- 乳腺组织球体培养领域发表文献最多的商用培养基
科学资源
Key Applications
Normal Breast Cell Lines
MCF10A
Kendellen MF et al. (2014) Canonical and non-canonical NF-κB signaling promotes breast cancer tumor-initiating cells. Oncogene 33(10): 1297-305.
MCF10A-SNAl1, MCF10A-SNAl1-R
Lim S et al. (2013) SNAI1-mediated epithelial-mesenchymal transition confers chemoresistance and cellular plasticity by regulating genes involved in cell death and stem cell maintenance. PLoS One 8(6): e66558.
HMLER
Burke AR et al. (2012) The resistance of breast cancer stem cells to conventional hyperthermia and their sensitivity to nanoparticle-mediated photothermal therapy. Biomaterials 33(10): 2961-70.
Qiao Y et al. (2011) FOXQ1 regulates epithelial-mesenchymal transition in human cancers. Cancer Res 71(8):3076-86.
Kendellen MF et al. (2014) Canonical and non-canonical NF-κB signaling promotes breast cancer tumor-initiating cells. Oncogene 33(10): 1297-305.
MCF10A-SNAl1, MCF10A-SNAl1-R
Lim S et al. (2013) SNAI1-mediated epithelial-mesenchymal transition confers chemoresistance and cellular plasticity by regulating genes involved in cell death and stem cell maintenance. PLoS One 8(6): e66558.
HMLER
Burke AR et al. (2012) The resistance of breast cancer stem cells to conventional hyperthermia and their sensitivity to nanoparticle-mediated photothermal therapy. Biomaterials 33(10): 2961-70.
Qiao Y et al. (2011) FOXQ1 regulates epithelial-mesenchymal transition in human cancers. Cancer Res 71(8):3076-86.
Breast Cancer Cell Lines
HBL-100
Smart CE et al. (2013) In vitro analysis of breast cancer cell line tumourspheres and primary human breast epithelia mammospheres demonstrates inter- and intrasphere heterogeneity. PLoS One 8(6): e64388.
KPL-1
Smart CE et al. (2013) In vitro analysis of breast cancer cell line tumourspheres and primary human breast epithelia mammospheres demonstrates inter- and intrasphere heterogeneity. PLoS One 8(6): e64388.
MDA-MB-453
Zhao S et al. (2013) HER2 overexpression-mediated inflammatory signaling enhances mammosphere formation through up-regulation of aryl hydrocarbon receptor transcription. Cancer Lett 330(1): 41-8.
SUM 159
Kendellen MF et al. (2014) Canonical and non-canonical NF-κB signaling promotes breast cancer tumor-initiating cells. Oncogene 33(10): 1297-305.
Smart CE et al. (2013) In vitro analysis of breast cancer cell line tumourspheres and primary human breast epithelia mammospheres demonstrates inter- and intrasphere heterogeneity. PLoS One 8(6): e64388.
Del Vecchio CA et al. (2012) Epidermal Growth Factor Receptor Variant III Contributes to Cancer Stem Cell Phenotypes in Invasive Breast Carcinoma. Cancer Res 72(10): 2657-71.
Korkaya H et al. (2012) Activation of an IL6 Inflammatory Loop Mediates Trastuzumab Resistance in HER2+ Breast Cancer by Expanding the Cancer Stem Cell Population. Mol Cell 47(4): 570-84.
BT-20
Smart CE et al. (2013) In vitro analysis of breast cancer cell line tumourspheres and primary human breast epithelia mammospheres demonstrates inter- and intrasphere heterogeneity. PLoS One 8(6): e64388.
HCC202
Deng et al. (2010) Distinct expression levels and patterns of stem cell marker, aldehyde dehydrogenase isoform 1 (ALDH1), in human epithelial cancers. PLoS One 5(4): e10277.
MCF7
D'Assoro AB et al. (2014) The mitotic kinase Aurora-A promotes distant metastases by inducing epithelial-to-mesenchymal transition in ERα(+) breast cancer cells. Oncogene 33(5): 599-610.
Kundu N et al. (2014) Prostaglandin E receptor EP4 is a therapeutic target in breast cancer cells with stem-like properties. Breast Cancer Res Treat 143(1): 19-31.
Rajabi H et al. (2014) MUC1-C oncoprotein activates the ZEB1/miR-200c regulatory loop and epithelial-mesenchymal transition. Oncogene 33(13): 1680-9.
Alam M et al. (2013) MUC1-C Oncoprotein Activates ERK->C/EBPβ Signaling and Induction of Aldehyde Dehydrogenase 1A1 in Breast Cancer Cells. J Biol Chem 288(43): 30892-903.
Bhat-Nakshatri P et al. (2013) Identification of FDA-approved drugs targeting breast cancer stem cells along with biomarkers of sensitivity. Sci Rep 3: 2530.
Bianco C et al. (2013) Regulation of human Cripto-1 expression by nuclear receptors and DNA promoter methylation in human embryonal and breast cancer cells. J Cell Physiol 228(6): 1174-88.
Cho JH et al. (2013) A positive feedback loop regulates the expression of polycomb group protein BMI1 via WNT signaling pathway. J Biol Chem 288(5): 3406-18.
Lee JH et al. (2013) The combination of sorafenib and radiation preferentially inhibits breast cancer stem cells by suppressing HIF-1α expression. Oncol Rep 29(3): 917-24.
Smart CE et al. (2013) In vitro analysis of breast cancer cell line tumourspheres and primary human breast epithelia mammospheres demonstrates inter- and intrasphere heterogeneity. PLoS One 8(6): e64388.
Vares G et al. (2013) Generation of breast cancer stem cells by steroid hormones in irradiated human mammary cell lines. PLoS One 8(10): e77124.
Wei X et al. (2013) Hyaluronic acid-based nanogel-drug conjugates with enhanced anticancer activity designed for the targeting of CD44-positive and drug-resistant tumors. Bioconjug Chem 24(4): 658-68.
Wolf J et al. (2013) A mammosphere formation RNAi screen reveals that ATG4A promotes a breast cancer stem-like phenotype. Breast Cancer Res 15(6): R109.
Zhao S et al. (2013) HER2 overexpression-mediated inflammatory signaling enhances mammosphere formation through up-regulation of aryl hydrocarbon receptor transcription. Cancer Lett 330(1): 41-8.
Gilani RA et al. (2012) The importance of HER2 signaling in the tumor-initiating cell population in aromatase inhibitor-resistant breast cancer. Breast Cancer Res Treat 135(3): 681-92.
Korkaya H et al. (2012) Activation of an IL6 Inflammatory Loop Mediates Trastuzumab Resistance in HER2+ Breast Cancer by Expanding the Cancer Stem Cell Population. Mol Cell (47(4): 570-84.
Palaniyandi K et al. (2012) Human Breast Cancer Stem Cells Have Significantly Higher Rate of Clathrin-Independent and Caveolin-Independent Endocytosis than the Differentiated Breast Cancer Cells. J Cancer Sci Ther 4(7): 214-222.
Wong NK et al. (2012) Heterogeneity of breast cancer stem cells as evidenced with Notch-dependent and Notch-independent populations. Cancer Med 1(2): 105-13.
Wu F et al. (2012) Identification of two novel phenotypically distinct breast cancer cell subsets based on Sox2 transcription activity. Cell Signal 24(11): 1989-98.
Zhao S et al. (2012) Activation of the aryl hydrocarbon receptor represses mammosphere formation in MCF-7 cells. Cancer Lett 317(2): 192-8.
Kumar A et al. (2011) Evidence that aberrant expression of tissue transglutaminase promotes stem cell characteristics in mammary epithelial cells. PLoS One 6(6): e20701.
Deng et al. (2010) Distinct expression levels and patterns of stem cell marker, aldehyde dehydrogenase isoform 1 (ALDH1), in human epithelial cancers. PLoS One 5(4): e10277.
MDA-MB-468
Alam M et al. (2013) MUC1-C Oncoprotein Activates ERK->C/EBPβ Signaling and Induction of Aldehyde Dehydrogenase 1A1 in Breast Cancer Cells. J Biol Chem 288(43): 30892-903.
T-47D
Axlund SD et al. (2013) Progesterone-inducible cytokeratin 5-positive cells in luminal breast cancer exhibit progenitor properties. Horm Cancer 4(1): 36-49.
Smart CE et al. (2013) In vitro analysis of breast cancer cell line tumourspheres and primary human breast epithelia mammospheres demonstrates inter- and intrasphere heterogeneity. PLoS One 8(6): e64388.
Vares G et al. (2013) Generation of breast cancer stem cells by steroid hormones in irradiated human mammary cell lines. PLoS One 8(10): e77124.
Deng et al. (2010) Distinct expression levels and patterns of stem cell marker, aldehyde dehydrogenase isoform 1 (ALDH1), in human epithelial cancers. PLoS One 5(4): e10277.
BT-474
D'Assoro AB et al. (2014) The mitotic kinase Aurora-A promotes distant metastases by inducing epithelial-to-mesenchymal transition in ERα(+) breast cancer cells. Oncogene 33(5): 599-610.
Smart CE et al. (2013) In vitro analysis of breast cancer cell line tumourspheres and primary human breast epithelia mammospheres demonstrates inter- and intrasphere heterogeneity. PLoS One 8(6): e64388.
HCC1599
Zhang CC et al. (2012) Biomarker and pharmacologic evaluation of the γ-secretase inhibitor PF-03084014 in breast cancer models. Clin Cancer Res 18(18): 5008-19.
MDA-MB-231
D'Assoro AB et al. (2014) The mitotic kinase Aurora-A promotes distant metastases by inducing epithelial-to-mesenchymal transition in ERα(+) breast cancer cells. Oncogene 33(5): 599-610.
Kendellen MF et al. (2014) Canonical and non-canonical NF-κB signaling promotes breast cancer tumor-initiating cells. Oncogene 33(10): 1297-305.
Kundu N et al. (2014) Prostaglandin E receptor EP4 is a therapeutic target in breast cancer cells with stem-like properties. Breast Cancer Res 143(1): 19-31.
Rajabi H et al. (2014) MUC1-C oncoprotein activates the ZEB1/miR-200c regulatory loop and epithelial-mesenchymal transition. Oncogene 33(13): 1680-9.
Bhat-Nakshatri P et al. (2013) Identification of FDA-approved drugs targeting breast cancer stem cells along with biomarkers of sensitivity. Sci Rep 3: 2530.
Dai L et al. (2013) CD147-dependent heterogeneity in malignant and chemoresistant properties of cancer cells. Am J Pathol 182(2): 577-85.
Di Cello F et al. (2013) Knockdown of HMGA1 inhibits human breast cancer cell growth and metastasis in immunodeficient mice. Biochem Biophys Res Commun 434(1): 70-4.
Han YK et al. (2013) A possible usage of a CDK4 inhibitor for breast cancer stem cell-targeted therapy. Biochem Biophys Res Commun 430(4): 1329-33.
Lee JH et al. (2013) The combination of sorafenib and radiation preferentially inhibits breast cancer stem cells by suppressing HIF-1α expression. Oncol Rep 29(3): 917-24.
Lim S et al. (2013) SNAI1-mediated epithelial-mesenchymal transition confers chemoresistance and cellular plasticity by regulating genes involved in cell death and stem cell maintenance. PLoS One 8(6): e66558.
Shen J et al. (2013) High Capacity Nanoporous Silicon Carrier for Systemic Delivery of Gene Silencing Therapeutics. ACS Nano 7(11): 9867-80.
Wolf J et al. (2013) A mammosphere formation RNAi screen reveals that ATG4A promotes a breast cancer stem-like phenotype. Breast Cancer Res 15(6): R109.
Hu K et al. (2012) Small interfering RNA library screen identified polo-like kinase-1 (PLK1) as a potential therapeutic target for breast cancer that uniquely eliminates tumor-initiating cells. Breast Cancer Res 14(1): R22.
Rao R et al. (2012) Combination of pan-histone deacetylase inhibitor and autophagy inhibitor exerts superior efficacy against triple-negative human breast cancer cells. Mol Cancer Ther 11(4): 973-83.
Stratford AL et al. (2012) Targeting p90 ribosomal S6 kinase eliminates tumor-initiating cells by inactivating Y-box binding protein-1 in triple-negative breast cancers. Stem Cells 30(7): 1338-48.
SKBR3
Kundu N et al. (2014) Prostaglandin E receptor EP4 is a therapeutic target in breast cancer cells with stem-like properties. Breast Cancer Res 143(1): 19-31.
Alam M et al. (2013) MUC1-C Oncoprotein Activates ERK->C/EBPβ Signaling and Induction of Aldehyde Dehydrogenase 1A1 in Breast Cancer Cells. J Biol Chem 288(43): 30892-903.
Smart CE et al. (2013) In vitro analysis of breast cancer cell line tumourspheres and primary human breast epithelia mammospheres demonstrates inter- and intrasphere heterogeneity. PLoS One 8(6): e64388.
TMD-231
Bhat-Nakshatri P et al. (2013) Identification of FDA-approved drugs targeting breast cancer stem cells along with biomarkers of sensitivity. Sci Rep 3: 2530.
GI-101A
Wang H et al. (2012) Oncolytic vaccinia virus GLV-1h68 strain shows enhanced replication in human breast cancer stem-like cells in comparison to breast cancer cells. J Transl Med 10(1): 167.
Hs578T
Smart CE et al. (2013) In vitro analysis of breast cancer cell line tumourspheres and primary human breast epithelia mammospheres demonstrates inter- and intrasphere heterogeneity. PLoS One 8(6): e64388.
MDA-MB-436
Bhat-Nakshatri P et al. (2013) Identification of FDA-approved drugs targeting breast cancer stem cells along with biomarkers of sensitivity. Sci Rep 3: 2530.
Smart CE et al. (2013) In vitro analysis of breast cancer cell line tumourspheres and primary human breast epithelia mammospheres demonstrates inter- and intrasphere heterogeneity. PLoS One 8(6): e64388.
SUM149
D'Assoro AB et al. (2014) The mitotic kinase Aurora-A promotes distant metastases by inducing epithelial-to-mesenchymal transition in ERα(+) breast cancer cells. Oncogene 33(5): 599-610.
Kendellen MF et al. (2014) Canonical and non-canonical NF-κB signaling promotes breast cancer tumor-initiating cells. Oncogene 33(10): 1297-305.
Qiu M et al. (2013) Specific inhibition of Notch1 signaling enhances the antitumor efficacy of chemotherapy in triple negative breast cancer through reduction of cancer stem cells. Cancer Lett 328(2): 261-70.
Wolf J et al. (2013) A mammosphere formation RNAi screen reveals that ATG4A promotes a breast cancer stem-like phenotype. Breast Cancer Res 15(6): R109.
Del Vecchio CA et al. (2012) Epidermal Growth Factor Receptor Variant III Contributes to Cancer Stem Cell Phenotypes in Invasive Breast Carcinoma. Cancer Res 72(10): 2657-71.
Hu K et al. (2012) Small interfering RNA library screen identified polo-like kinase-1 (PLK1) as a potential therapeutic target for breast cancer that uniquely eliminates tumor-initiating cells. Breast Cancer Res 14(1): R22.
Stratford AL et al. (2012) Targeting p90 ribosomal S6 kinase eliminates tumor-initiating cells by inactivating Y-box binding protein-1 in triple-negative breast cancers. Stem Cells 30(7): 1338-48.
Zhang CC et al. (2012) Biomarker and pharmacologic evaluation of the γ-secretase inhibitor PF-03084014 in breast cancer models. Clin Cancer Res 18(18): 5008-19.
ZR-75-1
Wu F et al. (2012) Identification of two novel phenotypically distinct breast cancer cell subsets based on Sox2 transcription activity. Cell Signal 24(11): 1989-98.
Deng et al. (2010) Distinct expression levels and patterns of stem cell marker, aldehyde dehydrogenase isoform 1 (ALDH1), in human epithelial cancers. PLoS One 5(4): e10277.
Smart CE et al. (2013) In vitro analysis of breast cancer cell line tumourspheres and primary human breast epithelia mammospheres demonstrates inter- and intrasphere heterogeneity. PLoS One 8(6): e64388.
KPL-1
Smart CE et al. (2013) In vitro analysis of breast cancer cell line tumourspheres and primary human breast epithelia mammospheres demonstrates inter- and intrasphere heterogeneity. PLoS One 8(6): e64388.
MDA-MB-453
Zhao S et al. (2013) HER2 overexpression-mediated inflammatory signaling enhances mammosphere formation through up-regulation of aryl hydrocarbon receptor transcription. Cancer Lett 330(1): 41-8.
SUM 159
Kendellen MF et al. (2014) Canonical and non-canonical NF-κB signaling promotes breast cancer tumor-initiating cells. Oncogene 33(10): 1297-305.
Smart CE et al. (2013) In vitro analysis of breast cancer cell line tumourspheres and primary human breast epithelia mammospheres demonstrates inter- and intrasphere heterogeneity. PLoS One 8(6): e64388.
Del Vecchio CA et al. (2012) Epidermal Growth Factor Receptor Variant III Contributes to Cancer Stem Cell Phenotypes in Invasive Breast Carcinoma. Cancer Res 72(10): 2657-71.
Korkaya H et al. (2012) Activation of an IL6 Inflammatory Loop Mediates Trastuzumab Resistance in HER2+ Breast Cancer by Expanding the Cancer Stem Cell Population. Mol Cell 47(4): 570-84.
BT-20
Smart CE et al. (2013) In vitro analysis of breast cancer cell line tumourspheres and primary human breast epithelia mammospheres demonstrates inter- and intrasphere heterogeneity. PLoS One 8(6): e64388.
HCC202
Deng et al. (2010) Distinct expression levels and patterns of stem cell marker, aldehyde dehydrogenase isoform 1 (ALDH1), in human epithelial cancers. PLoS One 5(4): e10277.
MCF7
D'Assoro AB et al. (2014) The mitotic kinase Aurora-A promotes distant metastases by inducing epithelial-to-mesenchymal transition in ERα(+) breast cancer cells. Oncogene 33(5): 599-610.
Kundu N et al. (2014) Prostaglandin E receptor EP4 is a therapeutic target in breast cancer cells with stem-like properties. Breast Cancer Res Treat 143(1): 19-31.
Rajabi H et al. (2014) MUC1-C oncoprotein activates the ZEB1/miR-200c regulatory loop and epithelial-mesenchymal transition. Oncogene 33(13): 1680-9.
Alam M et al. (2013) MUC1-C Oncoprotein Activates ERK->C/EBPβ Signaling and Induction of Aldehyde Dehydrogenase 1A1 in Breast Cancer Cells. J Biol Chem 288(43): 30892-903.
Bhat-Nakshatri P et al. (2013) Identification of FDA-approved drugs targeting breast cancer stem cells along with biomarkers of sensitivity. Sci Rep 3: 2530.
Bianco C et al. (2013) Regulation of human Cripto-1 expression by nuclear receptors and DNA promoter methylation in human embryonal and breast cancer cells. J Cell Physiol 228(6): 1174-88.
Cho JH et al. (2013) A positive feedback loop regulates the expression of polycomb group protein BMI1 via WNT signaling pathway. J Biol Chem 288(5): 3406-18.
Lee JH et al. (2013) The combination of sorafenib and radiation preferentially inhibits breast cancer stem cells by suppressing HIF-1α expression. Oncol Rep 29(3): 917-24.
Smart CE et al. (2013) In vitro analysis of breast cancer cell line tumourspheres and primary human breast epithelia mammospheres demonstrates inter- and intrasphere heterogeneity. PLoS One 8(6): e64388.
Vares G et al. (2013) Generation of breast cancer stem cells by steroid hormones in irradiated human mammary cell lines. PLoS One 8(10): e77124.
Wei X et al. (2013) Hyaluronic acid-based nanogel-drug conjugates with enhanced anticancer activity designed for the targeting of CD44-positive and drug-resistant tumors. Bioconjug Chem 24(4): 658-68.
Wolf J et al. (2013) A mammosphere formation RNAi screen reveals that ATG4A promotes a breast cancer stem-like phenotype. Breast Cancer Res 15(6): R109.
Zhao S et al. (2013) HER2 overexpression-mediated inflammatory signaling enhances mammosphere formation through up-regulation of aryl hydrocarbon receptor transcription. Cancer Lett 330(1): 41-8.
Gilani RA et al. (2012) The importance of HER2 signaling in the tumor-initiating cell population in aromatase inhibitor-resistant breast cancer. Breast Cancer Res Treat 135(3): 681-92.
Korkaya H et al. (2012) Activation of an IL6 Inflammatory Loop Mediates Trastuzumab Resistance in HER2+ Breast Cancer by Expanding the Cancer Stem Cell Population. Mol Cell (47(4): 570-84.
Palaniyandi K et al. (2012) Human Breast Cancer Stem Cells Have Significantly Higher Rate of Clathrin-Independent and Caveolin-Independent Endocytosis than the Differentiated Breast Cancer Cells. J Cancer Sci Ther 4(7): 214-222.
Wong NK et al. (2012) Heterogeneity of breast cancer stem cells as evidenced with Notch-dependent and Notch-independent populations. Cancer Med 1(2): 105-13.
Wu F et al. (2012) Identification of two novel phenotypically distinct breast cancer cell subsets based on Sox2 transcription activity. Cell Signal 24(11): 1989-98.
Zhao S et al. (2012) Activation of the aryl hydrocarbon receptor represses mammosphere formation in MCF-7 cells. Cancer Lett 317(2): 192-8.
Kumar A et al. (2011) Evidence that aberrant expression of tissue transglutaminase promotes stem cell characteristics in mammary epithelial cells. PLoS One 6(6): e20701.
Deng et al. (2010) Distinct expression levels and patterns of stem cell marker, aldehyde dehydrogenase isoform 1 (ALDH1), in human epithelial cancers. PLoS One 5(4): e10277.
MDA-MB-468
Alam M et al. (2013) MUC1-C Oncoprotein Activates ERK->C/EBPβ Signaling and Induction of Aldehyde Dehydrogenase 1A1 in Breast Cancer Cells. J Biol Chem 288(43): 30892-903.
T-47D
Axlund SD et al. (2013) Progesterone-inducible cytokeratin 5-positive cells in luminal breast cancer exhibit progenitor properties. Horm Cancer 4(1): 36-49.
Smart CE et al. (2013) In vitro analysis of breast cancer cell line tumourspheres and primary human breast epithelia mammospheres demonstrates inter- and intrasphere heterogeneity. PLoS One 8(6): e64388.
Vares G et al. (2013) Generation of breast cancer stem cells by steroid hormones in irradiated human mammary cell lines. PLoS One 8(10): e77124.
Deng et al. (2010) Distinct expression levels and patterns of stem cell marker, aldehyde dehydrogenase isoform 1 (ALDH1), in human epithelial cancers. PLoS One 5(4): e10277.
BT-474
D'Assoro AB et al. (2014) The mitotic kinase Aurora-A promotes distant metastases by inducing epithelial-to-mesenchymal transition in ERα(+) breast cancer cells. Oncogene 33(5): 599-610.
Smart CE et al. (2013) In vitro analysis of breast cancer cell line tumourspheres and primary human breast epithelia mammospheres demonstrates inter- and intrasphere heterogeneity. PLoS One 8(6): e64388.
HCC1599
Zhang CC et al. (2012) Biomarker and pharmacologic evaluation of the γ-secretase inhibitor PF-03084014 in breast cancer models. Clin Cancer Res 18(18): 5008-19.
MDA-MB-231
D'Assoro AB et al. (2014) The mitotic kinase Aurora-A promotes distant metastases by inducing epithelial-to-mesenchymal transition in ERα(+) breast cancer cells. Oncogene 33(5): 599-610.
Kendellen MF et al. (2014) Canonical and non-canonical NF-κB signaling promotes breast cancer tumor-initiating cells. Oncogene 33(10): 1297-305.
Kundu N et al. (2014) Prostaglandin E receptor EP4 is a therapeutic target in breast cancer cells with stem-like properties. Breast Cancer Res 143(1): 19-31.
Rajabi H et al. (2014) MUC1-C oncoprotein activates the ZEB1/miR-200c regulatory loop and epithelial-mesenchymal transition. Oncogene 33(13): 1680-9.
Bhat-Nakshatri P et al. (2013) Identification of FDA-approved drugs targeting breast cancer stem cells along with biomarkers of sensitivity. Sci Rep 3: 2530.
Dai L et al. (2013) CD147-dependent heterogeneity in malignant and chemoresistant properties of cancer cells. Am J Pathol 182(2): 577-85.
Di Cello F et al. (2013) Knockdown of HMGA1 inhibits human breast cancer cell growth and metastasis in immunodeficient mice. Biochem Biophys Res Commun 434(1): 70-4.
Han YK et al. (2013) A possible usage of a CDK4 inhibitor for breast cancer stem cell-targeted therapy. Biochem Biophys Res Commun 430(4): 1329-33.
Lee JH et al. (2013) The combination of sorafenib and radiation preferentially inhibits breast cancer stem cells by suppressing HIF-1α expression. Oncol Rep 29(3): 917-24.
Lim S et al. (2013) SNAI1-mediated epithelial-mesenchymal transition confers chemoresistance and cellular plasticity by regulating genes involved in cell death and stem cell maintenance. PLoS One 8(6): e66558.
Shen J et al. (2013) High Capacity Nanoporous Silicon Carrier for Systemic Delivery of Gene Silencing Therapeutics. ACS Nano 7(11): 9867-80.
Wolf J et al. (2013) A mammosphere formation RNAi screen reveals that ATG4A promotes a breast cancer stem-like phenotype. Breast Cancer Res 15(6): R109.
Hu K et al. (2012) Small interfering RNA library screen identified polo-like kinase-1 (PLK1) as a potential therapeutic target for breast cancer that uniquely eliminates tumor-initiating cells. Breast Cancer Res 14(1): R22.
Rao R et al. (2012) Combination of pan-histone deacetylase inhibitor and autophagy inhibitor exerts superior efficacy against triple-negative human breast cancer cells. Mol Cancer Ther 11(4): 973-83.
Stratford AL et al. (2012) Targeting p90 ribosomal S6 kinase eliminates tumor-initiating cells by inactivating Y-box binding protein-1 in triple-negative breast cancers. Stem Cells 30(7): 1338-48.
SKBR3
Kundu N et al. (2014) Prostaglandin E receptor EP4 is a therapeutic target in breast cancer cells with stem-like properties. Breast Cancer Res 143(1): 19-31.
Alam M et al. (2013) MUC1-C Oncoprotein Activates ERK->C/EBPβ Signaling and Induction of Aldehyde Dehydrogenase 1A1 in Breast Cancer Cells. J Biol Chem 288(43): 30892-903.
Smart CE et al. (2013) In vitro analysis of breast cancer cell line tumourspheres and primary human breast epithelia mammospheres demonstrates inter- and intrasphere heterogeneity. PLoS One 8(6): e64388.
TMD-231
Bhat-Nakshatri P et al. (2013) Identification of FDA-approved drugs targeting breast cancer stem cells along with biomarkers of sensitivity. Sci Rep 3: 2530.
GI-101A
Wang H et al. (2012) Oncolytic vaccinia virus GLV-1h68 strain shows enhanced replication in human breast cancer stem-like cells in comparison to breast cancer cells. J Transl Med 10(1): 167.
Hs578T
Smart CE et al. (2013) In vitro analysis of breast cancer cell line tumourspheres and primary human breast epithelia mammospheres demonstrates inter- and intrasphere heterogeneity. PLoS One 8(6): e64388.
MDA-MB-436
Bhat-Nakshatri P et al. (2013) Identification of FDA-approved drugs targeting breast cancer stem cells along with biomarkers of sensitivity. Sci Rep 3: 2530.
Smart CE et al. (2013) In vitro analysis of breast cancer cell line tumourspheres and primary human breast epithelia mammospheres demonstrates inter- and intrasphere heterogeneity. PLoS One 8(6): e64388.
SUM149
D'Assoro AB et al. (2014) The mitotic kinase Aurora-A promotes distant metastases by inducing epithelial-to-mesenchymal transition in ERα(+) breast cancer cells. Oncogene 33(5): 599-610.
Kendellen MF et al. (2014) Canonical and non-canonical NF-κB signaling promotes breast cancer tumor-initiating cells. Oncogene 33(10): 1297-305.
Qiu M et al. (2013) Specific inhibition of Notch1 signaling enhances the antitumor efficacy of chemotherapy in triple negative breast cancer through reduction of cancer stem cells. Cancer Lett 328(2): 261-70.
Wolf J et al. (2013) A mammosphere formation RNAi screen reveals that ATG4A promotes a breast cancer stem-like phenotype. Breast Cancer Res 15(6): R109.
Del Vecchio CA et al. (2012) Epidermal Growth Factor Receptor Variant III Contributes to Cancer Stem Cell Phenotypes in Invasive Breast Carcinoma. Cancer Res 72(10): 2657-71.
Hu K et al. (2012) Small interfering RNA library screen identified polo-like kinase-1 (PLK1) as a potential therapeutic target for breast cancer that uniquely eliminates tumor-initiating cells. Breast Cancer Res 14(1): R22.
Stratford AL et al. (2012) Targeting p90 ribosomal S6 kinase eliminates tumor-initiating cells by inactivating Y-box binding protein-1 in triple-negative breast cancers. Stem Cells 30(7): 1338-48.
Zhang CC et al. (2012) Biomarker and pharmacologic evaluation of the γ-secretase inhibitor PF-03084014 in breast cancer models. Clin Cancer Res 18(18): 5008-19.
ZR-75-1
Wu F et al. (2012) Identification of two novel phenotypically distinct breast cancer cell subsets based on Sox2 transcription activity. Cell Signal 24(11): 1989-98.
Deng et al. (2010) Distinct expression levels and patterns of stem cell marker, aldehyde dehydrogenase isoform 1 (ALDH1), in human epithelial cancers. PLoS One 5(4): e10277.
Other Tissues
Colon
KWu G et al. (2013) Clinical implications of periostin in the liver metastasis of colorectal cancer. Cancer Biother Radiopharm 28(4): 298-302.
Huang X et al. (2012) Co-expression of stem cell genes CD133 and CD44 in colorectal cancers with early liver metastasis. Surg Oncol 21(2): 103-7.
Lung
Hassan KA er al. (2013) Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma. Clin Cancer Res 19(8): 1972-80.
Nerve Sheath
Dai L et al. (2013) CD147-dependent heterogeneity in malignant and chemoresistant properties of cancer cells. Am J Pathol 182(2): 577-85.
Ovaries
Dai L et al. (2013) CD147-dependent heterogeneity in malignant and chemoresistant properties of cancer cells. Am J Pathol 182(2): 577-85.
Meng F et al. (2013) Anticancer efficacy of cisplatin and trichostatin A or 5-aza-2'-deoxycytidine on ovarian cancer. Br J Cancer 108(3): 579-86.
Meng F et al. (2013) Inhibition of DNA methyltransferases, histone deacetylases and lysine-specific demethylase-1 suppresses the tumorigenicity of the ovarian cancer ascites cell line SKOV3. Int J Oncol 43(2): 495-502.
Pease JC et al. (2012) Spontaneous spheroid budding from monolayers: a potential contribution to ovarian cancer dissemination. Biol Open 1(7): 622-8.
Xu CX et al. (2012) MicroRNA miR-214 regulates ovarian cancer cell stemness by targeting p53/Nanog. J Biol Chem 287(42): 34970-8.
KWu G et al. (2013) Clinical implications of periostin in the liver metastasis of colorectal cancer. Cancer Biother Radiopharm 28(4): 298-302.
Huang X et al. (2012) Co-expression of stem cell genes CD133 and CD44 in colorectal cancers with early liver metastasis. Surg Oncol 21(2): 103-7.
Lung
Hassan KA er al. (2013) Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma. Clin Cancer Res 19(8): 1972-80.
Nerve Sheath
Dai L et al. (2013) CD147-dependent heterogeneity in malignant and chemoresistant properties of cancer cells. Am J Pathol 182(2): 577-85.
Ovaries
Dai L et al. (2013) CD147-dependent heterogeneity in malignant and chemoresistant properties of cancer cells. Am J Pathol 182(2): 577-85.
Meng F et al. (2013) Anticancer efficacy of cisplatin and trichostatin A or 5-aza-2'-deoxycytidine on ovarian cancer. Br J Cancer 108(3): 579-86.
Meng F et al. (2013) Inhibition of DNA methyltransferases, histone deacetylases and lysine-specific demethylase-1 suppresses the tumorigenicity of the ovarian cancer ascites cell line SKOV3. Int J Oncol 43(2): 495-502.
Pease JC et al. (2012) Spontaneous spheroid budding from monolayers: a potential contribution to ovarian cancer dissemination. Biol Open 1(7): 622-8.
Xu CX et al. (2012) MicroRNA miR-214 regulates ovarian cancer cell stemness by targeting p53/Nanog. J Biol Chem 287(42): 34970-8.
