EasySep™小鼠TIL（CD45）正选试剂盒
产品号 #72552_C
WNT 通路抑制剂；抑制豪猪蛋白 (Porcupine)
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总览
WNT 生成抑制剂 4 (IWP-4) 通过抑制豪猪蛋白 (Porcupine) 来抑制 WNT 信号传导。豪猪蛋白是一种膜结合 O-酰基转移酶，负责对 WNT 蛋白进行棕榈酰化，而棕榈酰化对 WNT 信号传导能力和分泌至关重要（Chen et al.）。IWP-4 在体外可抑制 WNT 通路活性，IC50 值为 25 nM（Chen et al.）。
分化
·经 CHIR99021 处理后，可促进人多能干细胞向心肌细胞分化 (Lian et al., 2012, 2013; Sequiera et al.)。
·用BMP4和激活素A诱导原条（primitive streak）后，促进人胚胎干细胞向心肌细胞分化（Hudson et al.）。
细胞类型
心肌细胞，PSC衍生，多能干细胞
种属
人，小鼠，非人灵长类，其他物种，大鼠
应用
分化
研究领域
干细胞生物学
CAS 编号
686772-17-8
化学式
C₂₃H₂₀N₄O₃S₃
纯度
≥ 95 %
通路
WNT
靶点
Porcupine
产品说明书及文档
请在《产品说明书》中查找相关支持信息和使用说明，或浏览下方更多实验方案。
应用领域
本产品专为以下研究领域设计，适用于工作流程中的高亮阶段。探索这些工作流程，了解更多我们为各研究领域提供的其他配套产品。
相关材料与文献
技术资料 (3)
文献 (9)
Wnt signaling and cancer.
Genes & development 2000 AUG
Abstract
Wnt signalling in stem cells and cancer.
Nature 2005 APR
Abstract
The canonical Wnt cascade has emerged as a critical regulator of stem cells. In many tissues,activation of Wnt signalling has also been associated with cancer. This has raised the possibility that the tightly regulated self-renewal mediated by Wnt signalling in stem and progenitor cells is subverted in cancer cells to allow malignant proliferation. Insights gained from understanding how the Wnt pathway is integrally involved in both stem cell and cancer cell maintenance and growth in the intestinal,epidermal and haematopoietic systems may serve as a paradigm for understanding the dual nature of self-renewal signals.
Wnt/beta-catenin signaling in development and disease.
Cell 2006 NOV
Abstract
A remarkable interdisciplinary effort has unraveled the WNT (Wingless and INT-1) signal transduction cascade over the last two decades. Wnt genes encode small secreted proteins that are found in all animal genomes. Wnt signaling is involved in virtually every aspect of embryonic development and also controls homeostatic self-renewal in a number of adult tissues. Germline mutations in the Wnt pathway cause several hereditary diseases,and somatic mutations are associated with cancer of the intestine and a variety of other tissues.
更多信息
| 物种 | 人, 其它物种, 大鼠, 小鼠, 非人灵长类 |
|---|---|
| Cas Number | 686772-17-8 |
| Chemical Formula | C₂₃H₂₀N₄O₃S₃ |
| 纯度 | ≥ 95 % |
| Target | Porcupine |
| Pathway | WNT |
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