EasySep™小鼠TIL（CD45）正选试剂盒
产品号 #72262_C
维甲酸通路激活剂；激活视黄酸受体（RAR）
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总览
全反式视黄酸是维生素A的衍生物，作为维甲酸受体的配体（RAR, IC₅₀ = 14 nM）。RARs与视黄酸X受体（RXR）形成异二聚体，并与DNA中的视黄酸反应元件（RARE）结合，并作为转录因子改变基因表达。（Apfel et al., Chambon）
分化
·促进小鼠和人多能干细胞向运动神经元分化（Dimos et al., Wichterle et al.）。
·促进神经干细胞向神经元的分化（Takahashi et al.）。
·促进人胚胎干细胞（ES）向胰腺祖细胞分化（D'Amour et al.）。
·促进小鼠ES细胞向脂肪细胞分化（Dani et al.）。
·促进小鼠胚胎干细胞向心室心肌细胞分化（Wobus et al.）。
·促进粒细胞终末分化（Collins）。
癌症研究
·在急性早幼粒细胞白血病的分化治疗中促进母细胞成熟（Huang et al.）。
细胞类型
脂肪细胞，心肌细胞，PSC衍生，内胚层，PSC衍生，粒细胞及其亚群，白血病/淋巴瘤细胞，中胚层，PSC衍生，神经细胞，PSC衍生，神经元，胰腺细胞，多能干细胞
种属
人，小鼠，非人灵长类，其他物种，大鼠
应用
分化
研究领域
癌症，神经科学，干细胞生物学
CAS 编号
302-79-4
化学式
C₂₀H₂₈O₂
纯度
≥98%
通路
视黄醇类
靶点
RAR
产品说明书及文档
请在《产品说明书》中查找相关支持信息和使用说明，或浏览下方更多实验方案。
应用领域
本产品专为以下研究领域设计，适用于工作流程中的高亮阶段。探索这些工作流程，了解更多我们为各研究领域提供的其他配套产品。
相关材料与文献
技术资料 (5)
文献 (10)
Retinoic acid and neurotrophins collaborate to regulate neurogenesis in adult-derived neural stem cell cultures.
Journal of neurobiology 1999 JAN
Abstract
The adult rat hippocampus contains fibroblast growth factor 2-responsive stem cells that are self-renewing and have the ability to generate both neurons and glia in vitro,but little is known about the molecular events that regulate stem cell differentiation. Hippocampus-derived stem cell clones were used to examine the effects of retinoic acid (RA) on neuronal differentiation. Exposure to RA caused an immediate up-regulation of NeuroD,increased p21 expression,and concurrent exit from cell cycle. These changes were accompanied by a threefold increase in the number of cells differentiating into immature neurons. An accompanying effect of RA was to sustain or up-regulate trkA,trkB,trkC,and p75NGFR expression. Without RA treatment,cells were minimally responsive to neurotrophins (NTs),whereas the sequential application of RA followed by brain-derived neurotrophic factor or NT-3 led to a significant increase in neurons displaying mature y-a-minobutyric acid,acetylcholinesterase,tyrosine hydroxylase,or calbindin phenotypes. Although NTs promoted maturation,they had little effect on the total number of neurons generated,suggesting that RA and neurotrophins acted at distinct stages in neurogenesis. RA first promoted the acquisition of a neuronal fate,and NTs subsequently enhanced maturation by way of RA-dependent expression of the Trk receptors. In combination,these sequential effects were sufficient to stimulate stem cell-derived progenitors to differentiate into neurons displaying a variety of transmitter phenotypes.
Directed differentiation of embryonic stem cells into motor neurons.
Cell 2002 AUG
Abstract
Inductive signals and transcription factors involved in motor neuron generation have been identified,raising the question of whether these developmental insights can be used to direct stem cells to a motor neuron fate. We show that developmentally relevant signaling factors can induce mouse embryonic stem (ES) cells to differentiate into spinal progenitor cells,and subsequently into motor neurons,through a pathway recapitulating that used in vivo. ES cell-derived motor neurons can populate the embryonic spinal cord,extend axons,and form synapses with target muscles. Thus,inductive signals involved in normal pathways of neurogenesis can direct ES cells to form specific classes of CNS neurons.
The role of retinoids and retinoic acid receptors in normal hematopoiesis.
Leukemia 2002 OCT
Abstract
The dramatic therapeutic activity of all-trans retinoic acid (ATRA) in inducing terminal granulocytic differentiation of the malignant promyelocytes that characterize human acute promyelocytic leukemia (APL) has led to numerous studies assessing the role of retinoids and the retinoic acid receptors (RARs) in the regulation of normal hematopoiesis. Studies with knock out mice indicate that retinoic acid receptor activity is not essential for normal hematopoiesis,but both in vitro and in vivo studies indicate that these receptors may be important modifiers/regulators of different myeloid precursors/ progenitors including the primitive transplantable stem cell. A number of target genes have been identified that are either directly or indirectly regulated by RA receptors and which likely play important roles in the retinoid-mediated regulation of myelopoiesis. Several in vitro models of hematopoiesis suggest that the transcriptional activity of RA receptors is developmentally regulated during different stages of myelopoiesis. This regulation might involve non-ligand mediated molecular events that alter the interaction of RA receptors with transcriptional corepressor complexes. Moreover,the interaction of RA receptors with other families of transcription factors expressed in different hematopoietic lineages might also account for differential RA receptor activity at different stages of myelopoiesis.
更多信息
| 物种 | 人, 其它物种, 大鼠, 小鼠, 非人灵长类 |
|---|---|
| Cas Number | 302-79-4 |
| Chemical Formula | C₂₀H₂₈O₂ |
| 纯度 | ≥ 98% |
| Target | RAR |
| Pathway | Retinoid |
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质量保证:
产品仅供研究使用，不用于针对人或动物的诊断或治疗。 欲获悉更多关于STEMCELL的质控信息，请访问 STEMCELL.CN/COMPLIANCE. Safety Statement: CA WARNING: This product can expose you to All-trans Retinoic Acid which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov
产品仅供研究使用，不用于针对人或动物的诊断或治疗。 欲获悉更多关于STEMCELL的质控信息，请访问 STEMCELL.CN/COMPLIANCE. Safety Statement: CA WARNING: This product can expose you to All-trans Retinoic Acid which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov
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