EasySep™小鼠TIL（CD45）正选试剂盒
产品号 #72672_C
WNT通路抑制剂；抑制TNKS1和TNKS2
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总览
XAV939是一种高效的针对tankyrase（TNKS） 1和2的小分子抑制剂（IC50分别= 11和4 nM）（Huang et al.）。通过抑制TNKS活性，XAV939提高了 axin-GSK3β复合物的蛋白水平，并促进SW480细胞中β-连环素（β-catenin）的降解（Huang et al.），从而抑制了WNT通路的下游作用。
分化
·诱导小鼠胚胎干细胞的中胚层祖细胞的心肌分化（Wang等）。
·与SMAD抑制剂LDN193189和SB431542一起使用，可促进人多能干细胞前脑分化（Maroof et al.）。
癌症研究
·抑制APC缺失、β-连环素依赖的DLD-1结直肠癌细胞的克隆形成（Huang et al.）。
细胞类型
癌细胞及细胞系，心肌细胞，PSC衍生，神经细胞，PSC衍生，多能干细胞
种属
人，小鼠，非人灵长类，其他物种，大鼠
应用
分化
研究领域
癌症，神经科学，干细胞生物学
CAS 编号
284028-89-3
化学式
C₁₄H₁₁F₃N₂OS
纯度
≥98%
通路
WNT
靶点
TNKS
产品说明书及文档
请在《产品说明书》中查找相关支持信息和使用说明，或浏览下方更多实验方案。
应用领域
本产品专为以下研究领域设计，适用于工作流程中的高亮阶段。探索这些工作流程，了解更多我们为各研究领域提供的其他配套产品。
相关材料与文献
技术资料 (4)
文献 (7)
Wnt signaling and cancer.
Genes & development 2000 AUG
Abstract
Wnt signalling in stem cells and cancer.
Nature 2005 APR
Abstract
The canonical Wnt cascade has emerged as a critical regulator of stem cells. In many tissues,activation of Wnt signalling has also been associated with cancer. This has raised the possibility that the tightly regulated self-renewal mediated by Wnt signalling in stem and progenitor cells is subverted in cancer cells to allow malignant proliferation. Insights gained from understanding how the Wnt pathway is integrally involved in both stem cell and cancer cell maintenance and growth in the intestinal,epidermal and haematopoietic systems may serve as a paradigm for understanding the dual nature of self-renewal signals.
Wnt/beta-catenin signaling in development and disease.
Cell 2006 NOV
Abstract
A remarkable interdisciplinary effort has unraveled the WNT (Wingless and INT-1) signal transduction cascade over the last two decades. Wnt genes encode small secreted proteins that are found in all animal genomes. Wnt signaling is involved in virtually every aspect of embryonic development and also controls homeostatic self-renewal in a number of adult tissues. Germline mutations in the Wnt pathway cause several hereditary diseases,and somatic mutations are associated with cancer of the intestine and a variety of other tissues.
更多信息
| 物种 | 人, 其它物种, 大鼠, 小鼠, 非人灵长类 |
|---|---|
| Cas Number | 284028-89-3 |
| Chemical Formula | C₁₄H₁₁F₃N₂OS |
| 纯度 | ≥ 98% |
| Target | TNKS |
| Pathway | WNT |
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