EasySep™小鼠TIL（CD45）正选试剂盒
产品号 #72882_C
抗炎
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总览
青藤碱是一种天然植物生物碱，常用于缓解与类风湿性关节炎相关炎症（Wang and Li）。它可抑制核因子κ b (NF-κB）信号通路（Sun et al.; Wang and Li），通过抑制如P-糖蛋白等药物转运蛋白的作用，来提升某些化合物的生物利用度(Kesarwani et al.; Liu et al.)。
维持和自我更新
·促进人和小鼠胚胎干细胞的自我更新（Desbordes et al.）。
细胞类型
多能干细胞
种属
人，小鼠，非人灵长类，其他物种，大鼠
应用
扩增，培养
研究领域
干细胞生物学
CAS 编号
6080-33-7
化学式
C₁₉H₂₃NO₄ · HCl
纯度
≥98%
通路
NF-κB
产品说明书及文档
请在《产品说明书》中查找相关支持信息和使用说明，或浏览下方更多实验方案。
应用领域
本产品专为以下研究领域设计，适用于工作流程中的高亮阶段。探索这些工作流程，了解更多我们为各研究领域提供的其他配套产品。
相关材料与文献
技术资料 (1)
文献 (5)
High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells.
Cell stem cell 2008 JUN
Abstract
High-throughput screening (HTS) of chemical libraries has become a critical tool in basic biology and drug discovery. However,its implementation and the adaptation of high-content assays to human embryonic stem cells (hESCs) have been hampered by multiple technical challenges. Here we present a strategy to adapt hESCs to HTS conditions,resulting in an assay suitable for the discovery of small molecules that drive hESC self-renewal or differentiation. Use of this new assay has led to the identification of several marketed drugs and natural compounds promoting short-term hESC maintenance and compounds directing early lineage choice during differentiation. Global gene expression analysis upon drug treatment defines known and novel pathways correlated to hESC self-renewal and differentiation. Our results demonstrate feasibility of hESC-based HTS and enhance the repertoire of chemical compounds for manipulating hESC fate. The availability of high-content assays should accelerate progress in basic and translational hESC biology.
Immunosuppressive and anti-inflammatory activities of sinomenine.
International immunopharmacology 2011 MAR
Abstract
Sinomenine (SN),a pure compound extracted from the Sinomenium acutum plant,has been found to inhibit T- and B-lymphocyte activation,proliferation and function and to interfere with the differentiation,recruitment and function of several other cell types,such as dendritic cells (DC). SN has demonstrated its potential anti-inflammatory role for treating immune-related disorders in experimental animal models and in some clinical applications. This review will summarize its potential effects,mechanisms and applications.
Bioavailability enhancers of herbal origin: an overview.
Asian Pacific journal of tropical biomedicine 2013 APR
Abstract
Recently,the use of herbal medicines has been increased all over the world due to their therapeutic effects and fewer adverse effects as compared to the modern medicines. However,many herbal drugs and herbal extracts despite of their impressive in-vitro findings demonstrates less or negligible in-vivo activity due to their poor lipid solubility or improper molecular size,resulting in poor absorption and hence poor bioavailability. Nowadays with the advancement in the technology,novel drug delivery systems open the door towards the development of enhancing bioavailability of herbal drug delivery systems. For last one decade many novel carriers such as liposomes,microspheres,nanoparticles,transferosomes,ethosomes,lipid based systems etc. have been reported for successful modified delivery of various herbal drugs. Many herbal compounds including quercetin,genistein,naringin,sinomenine,piperine,glycyrrhizin and nitrile glycoside have demonstrated capability to enhance the bioavailability. The objective of this review is to summarize various available novel drug delivery technologies which have been developed for delivery of drugs (herbal),and to achieve better therapeutic response. An attempt has also been made to compile a profile on bioavailability enhancers of herbal origin with the mechanism of action (wherever reported) and studies on improvement in drug bioavailability,exhibited particularly by natural compounds.
更多信息
| 物种 | 人, 其它物种, 大鼠, 小鼠, 非人灵长类 |
|---|---|
| Cas Number | 6080-33-7 |
| Chemical Formula | C₁₉H₂₃NO₄ · HCl |
| 纯度 | ≥ 98% |
| Pathway | NF-κB |
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