This Episode's Immunology Roundup:

• How Viruses Cause Pyroptosis – Bcl-2 members MCL-1 and BCL-xL sense translation inhibition during viral infection, leading to Gasdermin E-dependent pyroptosis.
• Aging the Immune System – Researchers selectively deleted Ercc1, which encodes a crucial DNA repair protein, to increase senescence in the immune systems of mice, leading to systemic aging.
• Thymic Development of Microbiota-Specific T Cells – Scientists showed that intestinal colonization in early life leads to the trafficking of microbial antigens from the intestine to the thymus by intestinal dendritic cells, which then induce the expansion of microbiota-specific T cells.
• Antibody-Dependent Inflammation in COVID-19 – Researchers found that in patients with severe COVID-19, high titers and low fucosylation of anti-spike IgG leads to excessive inflammatory responses by alveolar macrophages.