This Episode's Stem Cell Roundup:

• Machine Learning and iPSC Approach for Drug Discovery – A machine learning approach has been developed to conduct network-based screens in iPSC-derived cells. The method identified a potential drug candidate for heart valve disease.
• Mapping the Developing Intestine – Using single-cell RNA sequencing and spatial transcriptomics, scientists have mapped the development of the human intestine over time.
• Sensory Neurons Promote HSC Mobilization – Scientists have shown that nociceptive nerves in the bone marrow, which are activated by external stimuli like ingestion of spicy foods, are required for hematopoietic stem cell mobilization.
• Understanding Intestinal Stem Cell Self-Renewal and Differentiation – Scientists have identified a specific intestinal stem cell niche signaling pathway, the Wnt/planar cell polarity pathway, that regulates intestinal stem cell self-renewal and lineage decisions.