Joseph R et al. (JUL 2016)
Investigative ophthalmology & visual science 57 8 3685--3697
Modeling Keratoconus Using Induced Pluripotent Stem Cells.
PURPOSE To model keratoconus (KC) using induced pluripotent stem cells (iPSC) generated from fibroblasts of both KC and normal human corneal stroma by a viral method. METHODS Both normal and KC corneal fibroblasts from four human donors were reprogramed directly by delivering reprogramming factors in a single virus using 2A self-cleaving" peptides�
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